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Some published studies have examined co-administration and found additive effects in certain models, though the mechanistic basis for interaction is not fully established
The 2.0mL option works well for the 4mg and 8mg phases but forces a split at 12mg
Researchers have firmly linked the use of these drugs to B12 deficiency although that possibility may not outweigh the need for the medication
The NICE (2022) CKS suggests that measuring vitamin B12 levels is unhelpful because they will rise regardless of effectiveness
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